According to the official website, MegaBus is going to expand service from Pittsburgh starting May 11th. They've added 9 new destinations that you can go to from Pittsburgh.
The cities are Cleveland, Detroit, Columbus, Toledo, Toronto, Erie, Buffalo, Akron, and Cinncinati.
IMO, this "midwest" connection couldn't come fast enough. Now I have two cities for me to hit up and transit-fan the crap out of!
For more information:
http://us.megabus.com/pittsburghhub.aspx